Towards an accurate identification of mosaic genes and partial horizontal gene transfers

Boc, A. et Makarenkov, V. (2011). « Towards an accurate identification of mosaic genes and partial horizontal gene transfers ». Nucleic Acids Research, 39(21), e144.

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Résumé

Many bacteria and viruses adapt to varying environmental conditions through the acquisition of mosaic genes. A mosaic gene is composed of alternating sequence polymorphisms either belonging to the host original allele or derived from the integrated donor DNA. Often, the integrated sequence contains a selectable genetic marker (e.g. marker allowing for antibiotic resistance). An effective identification of mosaic genes and detection of corresponding partial horizontal gene transfers (HGTs) are among the most important challenges posed by evolutionary biology. We developed a method for detecting partial HGT events and related intragenic recombination giving rise to the formation of mosaic genes. A bootstrap procedure incorporated in our method is used to assess the support of each predicted partial gene transfer. The proposed method can be also applied to confirm or discard complete (i.e. traditional) horizontal gene transfers detected by any HGT inferring method. While working on a fullgenome scale, the new method can be used to assess the level of mosaicism in the considered genomes as well as the rates of complete and partial HGT underlying their evolution.

Type: Article de revue scientifique
Mots-clés ou Sujets: mosaic genes, gene transfers
Unité d'appartenance: Faculté des sciences > Département d'informatique
Déposé par: Vladimir Makarenkov
Date de dépôt: 16 févr. 2016 15:06
Dernière modification: 20 avr. 2016 19:35
Adresse URL : http://www.archipel.uqam.ca/id/eprint/7829

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